Zhalilo L I, Susak Y M, Zemskov S V, Susak I A
Department of Physiology, Kiev Shevchenko University, Ukraine.
Drugs Exp Clin Res. 1996;22(3-5):189-91.
In our in-vitro experiments on the addition of Ukrain into an incubation solution of intact rat liver-cell homogenate, it was indicated that the effect of Ukrain depends on the metabolic redox chain. The endogenous respiration rate which is supported by ionic solution of incubation only, with Ukrain addition submits to a 25% decline. At the same time Ukrain stimulates NADP-dependent oxidation. Since the oxygen consumption increase under Ukrain's influence is characteristic of the metabolic state 4 of Chance (1956), it could be explained as a protonophoric effect (6). The data obtained indicate a complex mechanism of Ukrain's influence on the processes basic for the living organism, the breakage of which always leads to the pathological changes.
在我们关于将乌头碱添加到完整大鼠肝细胞匀浆孵育溶液中的体外实验中，结果表明乌头碱的作用取决于代谢氧化还原链。仅由孵育离子溶液支持的内源性呼吸速率，在添加乌头碱后下降了25%。同时，乌头碱刺激依赖于NADP的氧化。由于在乌头碱影响下耗氧量增加是钱斯（1956年）代谢状态4的特征，这可以解释为质子载体效应（6）。所获得的数据表明乌头碱对生物体基本过程的影响机制复杂，其破坏总是会导致病理变化。
