Ushio F, Fukuhara M, Bani M H, Narbonne J F
Department of Nutrition, Tokyo Metropolitan Research Laboratory of Public Health, Japan.
Int J Vitam Nutr Res. 1996;66(3):197-202.
Expression of hepatic cytochrome P450 isozymes by vitamin A-deficient or -supplemented diet was studied in Syrian hamsters. In male hamsters given a vitamin A-supplemented diet at a level of 250 IU/g-diet for 6 weeks, a marked increase in the activity of testosterone 7 alpha-hydroxylase was observed, accompanied by an elevation in the level of protein immunorelated to CYP2A1. In the hamsters fed a vitamin A-deficient diet for 6 weeks, a decrease was obtained in the total cytochrome P450 content and in the activities of most drug-metabolizing enzymes in livers.
在叙利亚仓鼠中研究了维生素A缺乏或补充饮食对肝细胞色素P450同工酶表达的影响。给雄性仓鼠喂食维生素A补充水平为250 IU/g-饮食的饲料6周后，观察到睾酮7α-羟化酶活性显著增加，同时与CYP2A1相关的蛋白质水平升高。在喂食维生素A缺乏饮食6周的仓鼠中，肝脏中总细胞色素P450含量以及大多数药物代谢酶的活性均有所下降。
