Ohno T, Ohinata H, Ogawa K, Kuroshima A
Medical Sciences Laboratory, Hokkaido University of Education, Asahikawa, Japan.
Jpn J Physiol. 1996 Jun;46(3):265-70. doi: 10.2170/jjphysiol.46.265.
The effects of cold acclimation and repetitive intermittent immobilization were examined on fatty acid (FA) compositions in phospholipids of rat interscapular brown adipose tissue (BAT) and plasma. As previously reported, cold acclimation and intermittent immobilization increased the degree of unsaturation as a whole in FAs of BAT but not in plasma. N-3 polyunsaturated docosahexaenoic acid (22-6; DHA) decreased in cold acclimation but increased in intermittent immobilization in phospholipids of BAT. DHA was decreased in phospholipids of plasma in both groups. Considering our previous findings that the in vitro thermogenic response of BAT was suppressed in cold acclimation and enhanced in intermittent immobilization, it was inferred that DHA in BAT is involved in the regulation of thermogenic function of this tissue.
研究了冷适应和重复性间歇性固定对大鼠肩胛间棕色脂肪组织（BAT）和血浆磷脂中脂肪酸（FA）组成的影响。如先前报道，冷适应和间歇性固定使BAT的脂肪酸整体不饱和程度增加，但血浆中未增加。在BAT磷脂中，N-3多不饱和二十二碳六烯酸（22:6；DHA）在冷适应时减少，但在间歇性固定时增加。两组血浆磷脂中的DHA均减少。鉴于我们之前的发现，即BAT的体外产热反应在冷适应时受到抑制，在间歇性固定时增强，推测BAT中的DHA参与了该组织产热功能的调节。
