Zhao F Q, Kennelly J J, Moseley W M, Tucker H A
Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Canada.
J Dairy Sci. 1996 Sep;79(9):1537-42. doi: 10.3168/jds.S0022-0302(96)76514-1.
Our objective was to study the effects of recombinant bovine growth hormone and bovine growth hormone-releasing factor on gene expression of glucose transporters in the liver and kidney of lactating cows. Primiparous cows received 29 mg/d of bovine growth hormone or 12 mg/d of bovine growth hormone-releasing factor by continuous intravenous infusion or no treatment (control) from 118 to 181 d postpartum. Growth hormone or growth hormone-releasing factor did not influence the mRNA abundance of the liver-type glucose transporter in the liver or kidney. Similarly, neither growth hormone-releasing factor nor growth hormone altered the mRNA abundance of the erythrocyte-type or the intestinal-type glucose transporter in the kidney, but large individual differences were observed in the mRNA abundance of the intestinal-type glucose transporter in liver.
我们的目的是研究重组牛生长激素和牛生长激素释放因子对泌乳母牛肝脏和肾脏中葡萄糖转运蛋白基因表达的影响。初产母牛在产后118至181天通过持续静脉输注接受29毫克/天的牛生长激素或12毫克/天的牛生长激素释放因子，或不接受治疗（对照）。生长激素或生长激素释放因子不影响肝脏或肾脏中肝型葡萄糖转运蛋白的mRNA丰度。同样，生长激素释放因子和生长激素均未改变肾脏中红细胞型或肠型葡萄糖转运蛋白的mRNA丰度，但在肝脏中肠型葡萄糖转运蛋白的mRNA丰度方面观察到较大的个体差异。
