Dryden S, Wang Q, Frankish H M, Williams G
Department of Medicine, University of Liverpool, UK.
Peptides. 1996;17(6):943-9. doi: 10.1016/0196-9781(96)00142-8.
To determine whether NPY and 5-HT interact, we studied the effects on hypothalamic NPY and NPY mRNA levels of acute (10 mg/kg) and 7-day administration (10 mg/kg/day) of mCPP (a 5-HT 1B/2C agonist) and flesinoxan (a 5-HT 1A agonist). After both treatments, mCPP reduced food intake and NPY levels in the PVN (p < 0.01). NPY mRNA levels were only increased by comparable food restriction (p < 0.05). Acute flesinoxan injection increased food intake and NPY levels in the PVN and ARC (p < 0.01). This suggests that food intake changes induced by mCPP and flesinoxan are associated with altered NPYergic activity. Stimulation of different hypothalamic 5-HT1 receptors may alter NPY levels available for release in the PVN, possibly by altering transport along the ARC-PVN projection. Therefore, inhibition of the ARC-PVN projection may at least partly mediate the hypophagic effects of serotonin.
为了确定神经肽Y（NPY）和5-羟色胺（5-HT）是否相互作用，我们研究了5-HT1B/2C激动剂mCPP和5-HT1A激动剂氟西汀对下丘脑NPY及NPY mRNA水平的影响，其中mCPP和氟西汀的给药方式分别为急性给药（10mg/kg）和连续7天给药（10mg/kg/天）。两种处理后，mCPP均降低了食物摄入量及室旁核（PVN）中的NPY水平（p<0.01）。只有在相当程度的食物限制下，NPY mRNA水平才会升高（p<0.05）。急性注射氟西汀增加了食物摄入量以及PVN和弓状核（ARC）中的NPY水平（p<0.01）。这表明mCPP和氟西汀引起的食物摄入量变化与NPY能活性改变有关。刺激不同的下丘脑5-HT1受体可能会改变可在PVN中释放的NPY水平，这可能是通过改变沿ARC-PVN投射的转运来实现的。因此，抑制ARC-PVN投射可能至少部分介导了5-羟色胺的促食欲作用。
