Glucosyl transferase activity and diabetic microangiopathy.

Thickening of the basement membrane and deposition of collagen-like substances in vascular lesions are well-known findings in diabetes mellitus, suggesting altered metabolism of glycoproteins. Glomerular glucosyltransferase activity were measured in normal and diabetic rats. Enzymic activity in diabetic animals did not differ from control. Another mechanism must be involved in the thickening of the B.M., such as increased production of hydroxylysine-rich peptides or decreased breakdown of B.M. materials.