Lezama-Dávila C M, Gallagher G
Centro de Investigaciónes en Enfermedades Tropicales, Universidad Autónoma de Campeche, Mexico.
In Vivo. 1995 Sep-Oct;9(5):519-24.
In this report, the effectiveness of vaccination of C57BL/6 mice and its association to long term production of IgG anti-Leishmania, delayed type hypersensitivity response (DTH) and the enlargement of the spleen associated to hyperplasia or parasite visceralization were studied. Mice were vaccinated with Leishmania-membrane antigens incorporated into liposomes, and two weeks later, animals received a homologous challenge with living amastigotes. Antibody levels were weekly recorded during 18 weeks after immunization. It was concluded that this vaccine induces disease-resistance in C57BL/6 mice and this effect correlates with the production of IgG anti-Leishmania, but not with the induction of a DTH or lymphoid hyperplasia.
在本报告中，研究了C57BL/6小鼠接种疫苗的有效性及其与抗利什曼原虫IgG的长期产生、迟发型超敏反应（DTH）以及与增生或寄生虫内脏化相关的脾脏肿大之间的关联。用掺入脂质体的利什曼原虫膜抗原对小鼠进行接种，两周后，动物接受活无鞭毛体的同源攻击。在免疫后的18周内每周记录抗体水平。得出的结论是，这种疫苗可诱导C57BL/6小鼠产生抗病性，且这种效应与抗利什曼原虫IgG的产生相关，但与DTH的诱导或淋巴样增生无关。
