Patacchioli F R, Di Grezia R, Angelucci L
Institute of Pharmacology, University of Rome La Sapienza, Italy.
Eur J Pharmacol. 1996 Mar 28;299(1-3):29-32. doi: 10.1016/0014-2999(95)00847-0.
This study determined the effects, in the rat, of 8-day treatment with arginine-aspartate on haloperidol-induced catalepsy, decrease of locomotor activity and change of striatal dopamine, homovanillic acid (HVA) and dihydroxy-phenylacetic acid (DOPAC) content. Arginine-aspartate was able to attenuate the haloperidol-induced decrease of locomotor activity and to significantly reduce the catalepsy. Moreover, arginine-aspartate treatment itself increased striatal dopamine content and produced a significant decrease of the HVA/dopamine ratio. Pretreatment with arginine-aspartate was able to partially counteract the haloperidol-induced changes of dopamine metabolism: the haloperidol-induced increases of the DOPAC/dopamine and HVA/dopamine ratios were significantly reduced in arginine-aspartate- pretreated rats. These results suggest that the action of arginine-aspartate on haloperidol-induced neurobehavioral effects is probably mediated by interference with striatal dopaminergic innervation.
本研究确定了在大鼠中，用精氨酸天冬氨酸进行8天治疗对氟哌啶醇诱导的僵住症、运动活性降低以及纹状体多巴胺、高香草酸（HVA）和二羟基苯乙酸（DOPAC）含量变化的影响。精氨酸天冬氨酸能够减轻氟哌啶醇诱导的运动活性降低，并显著减少僵住症。此外，精氨酸天冬氨酸治疗本身增加了纹状体多巴胺含量，并使HVA/多巴胺比值显著降低。用精氨酸天冬氨酸预处理能够部分抵消氟哌啶醇诱导的多巴胺代谢变化：在精氨酸天冬氨酸预处理的大鼠中，氟哌啶醇诱导的DOPAC/多巴胺和HVA/多巴胺比值升高显著降低。这些结果表明，精氨酸天冬氨酸对氟哌啶醇诱导的神经行为效应的作用可能是通过干扰纹状体多巴胺能神经支配来介导的。
