[Superantigens and their behavior in the immune response].

Superantigens are a group of molecules produced by bacteria, viruses and parasites that stimulate T lymphocytes in a very potent way. They join the TCR-HLA complex from the outside, not through the classical peptide-bound mechanism, so that they can easily trigger the citokyne production network and produce tissue damage, they can also lead to clonal anergy over the CD4 T cell subpopulations (Th0/Th1/Th2).