López H, Sandoval G F, Vera J G, Solano M O
inmunología clínica y alergia, Hospital Lic. Adolfo López Mateos, ISSSTE, México.
Rev Alerg Mex. 1996 Jan-Feb;43(1):13-7.
Superantigens are a group of molecules produced by bacteria, viruses and parasites that stimulate T lymphocytes in a very potent way. They join the TCR-HLA complex from the outside, not through the classical peptide-bound mechanism, so that they can easily trigger the citokyne production network and produce tissue damage, they can also lead to clonal anergy over the CD4 T cell subpopulations (Th0/Th1/Th2).
超抗原是由细菌、病毒和寄生虫产生的一类分子，它们能以非常有效的方式刺激T淋巴细胞。它们从外部结合TCR-HLA复合体，而非通过经典的肽结合机制，从而能够轻易触发细胞因子产生网络并造成组织损伤，它们还可导致CD4 T细胞亚群（Th0/Th1/Th2）出现克隆无能。
