Strasser R, Htun P, Schaper W
Max-Planck-Institute for Physiological and Clinical Research, Kerckhoff-Klinik, Bad Nauheim, Germany.
Mol Cell Biochem. 1996 Jul-Aug;160-161:209-15. doi: 10.1007/BF00240051.
Helmholtz is quoted to have said that if he'd had any influence in creation he would have returned the human eye to its maker for revisions. The same could be said of the heart with its only very rudimentary ability to defend itself against ischemia. Ischemia was obviously not a problem during evolution: Early man did not live much longer than prime time for reproduction and no selection bias existed to prevent vascular diseases, an affliction of later life. In spite of this natural disadvantage of aged males the number of existing although not very efficient defense mechanisms is surprisingly large. It is the general belief that the knowledge of these mechanisms may lead to the development of new therapies that hopefully improve the imperfect product of natural selection.
