暴露于1,3 - 丁二烯的人群中关于非癌症和癌症影响的未来研究需求。

Future research needs for non-cancer and cancer effects among populations exposed to 1,3-butadiene.

作者信息

Koppikar A M

机构信息

U.S. EPA, National Center for Environmental Assessment, Washington, DC 20460, USA.

出版信息

Toxicology. 1996 Oct 28;113(1-3):203-9. doi: 10.1016/0300-483x(96)03445-2.

DOI:10.1016/0300-483x(96)03445-2

PMID:8901899

Abstract

In the last decade there has been in-depth research into understanding the health effects of 1,3-butadiene in humans and in animals. With increasing knowledge of metabolism, pharmacokinetics and mechanism of action studied in animals, the uncertainties in risk assessment will be lessened. Still, some data gaps exist which, if filled, will be useful for meaningful risk assessments for the general population. This paper discusses the future needs for research in both non-cancer and cancer effects.

摘要

在过去十年里，人们对1,3 - 丁二烯对人类和动物健康影响进行了深入研究。随着对动物体内新陈代谢、药代动力学及作用机制的了解不断增加，风险评估中的不确定性将会降低。不过，仍存在一些数据空白，若能填补这些空白，将有助于对普通人群进行有意义的风险评估。本文讨论了在非癌症和癌症影响方面未来的研究需求。