阿替洛尔对犬心肌局部心肌血流及ST段抬高的影响。
Effects of atenolol on regional myocardial blood flow and ST segment elevation in the canine myocardium.
作者信息
Berdaux A, Bossier J R, Giudicelli J F
出版信息
Br J Pharmacol. 1977 Jul;60(3):433-9. doi: 10.1111/j.1476-5381.1977.tb07519.x.
Abstract
1 The effects of atenolol on regional myocardial blood flow (RMBF) and on ST segment elevation were studied both in normal and ischaemic regions of the myocardium in dogs. Some of the experiments were performed with cardiac pacing or after bilateral stellectomy. 2 In the absence of cardiac pacing, atenolol (1 mg/kg, i.v.) induced a marked reduction in heart rate and contractile force and a decrease in RMBF, which was of the same magnitude in normal and ischaemic areas. There was no modification in the endo/epi flow ratio. ST segment elevation in ischaemic areas was significantly reduced. 3 Bilateral stellectomy induced similar effects to those of atenolol. Atenolol after bilateral stellectomy exhibited no additional effects. 4 In dogs submitted to cardiac pacing, atenolol no longer decreased RMBF and ST segment elevation. 5 These results demonstrate that with atenolol, there is no correlation between bradycardia and the endo/epi flow ratio while there is one between bradycardia and reduction in ST segment elevation.
摘要
- 研究了阿替洛尔对犬心肌正常区域和缺血区域局部心肌血流量（RMBF）以及ST段抬高的影响。部分实验在心脏起搏或双侧星状神经节切除术后进行。2. 在无心脏起搏的情况下，阿替洛尔（1mg/kg，静脉注射）可显著降低心率和收缩力，并使RMBF减少，正常区域和缺血区域的减少幅度相同。内膜/外膜血流比值无改变。缺血区域的ST段抬高显著降低。3. 双侧星状神经节切除术产生的效果与阿替洛尔相似。双侧星状神经节切除术后使用阿替洛尔未显示出额外效果。4. 在接受心脏起搏的犬中，阿替洛尔不再降低RMBF和ST段抬高。5. 这些结果表明，使用阿替洛尔时，心动过缓与内膜/外膜血流比值之间无相关性，而心动过缓与ST段抬高降低之间存在相关性。
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