Goadsby P J, Edvinsson L
Institute of Neurology, National Hospital for Neurology and Neurosurgery, London, UK.
Cephalalgia. 1996 Oct;16(6):448-50. doi: 10.1046/j.1468-2982.1996.1606448.x.
Chronic paroxysmal hemicrania (CPH) is a rare headache syndrome of short-lasting attacks of pain, characterized clinically by trigemino-parasympathetic activation. The features of the headache are severe attacks of pain that generally last no more than minutes in association with autonomic activation, such as lacrimation or rhinorrhea. We report a patient fulfilling International Headache Society guidelines for the diagnosis of CPH in whom levels of calcitonin gene-related peptide (CGRP) and vasoactive intestinal polypeptide (VIP) were elevated in the cranial circulation during attacks. Moreover, successful treatment of the problem with indomethacin leads to normalization of the levels of both CGRP and VIP. Given that similar neuropeptide changes are seen in cluster headache the data suggest a shared underlying pathophysiology between CPH and cluster headache.
慢性阵发性偏侧头痛（CPH）是一种罕见的头痛综合征，以短暂性疼痛发作为特征，临床特点为三叉神经-副交感神经激活。头痛的特征是严重的疼痛发作，通常持续不超过几分钟，并伴有自主神经激活，如流泪或流涕。我们报告了一名符合国际头痛协会CPH诊断标准的患者，其发作期间颅内循环中降钙素基因相关肽（CGRP）和血管活性肠肽（VIP）水平升高。此外，用吲哚美辛成功治疗该问题后，CGRP和VIP水平均恢复正常。鉴于丛集性头痛中也观察到类似的神经肽变化，这些数据表明CPH和丛集性头痛之间存在共同的潜在病理生理学机制。
