Jamieson G G, Carter D C
Br J Surg. 1977 Feb;64(2):139-42. doi: 10.1002/bjs.1800640214.
The results of treatment of 48 cases of advanced cancer by quadruple chemotherapy are reported. In only 4 patients was an objective remission obtained, although equivocal remissions were observed in 9 patients. This report is at variance with other recent reports. The reasons for the discrepancy are discussed, and while combination chemotherapy may prove more effective if used earlier in the natural history of malignant disease, in this series the technique does not appear to offer any greater chance of remission than chemotherapeutic agents used singly.
报告了48例晚期癌症患者接受四联化疗的治疗结果。仅4例患者获得了客观缓解，尽管有9例患者观察到了不明确的缓解。本报告与其他近期报告不一致。讨论了差异的原因，虽然联合化疗如果在恶性疾病自然病程中更早使用可能会证明更有效，但在本系列中，该技术似乎并不比单独使用化疗药物提供更大的缓解机会。
