Ianuzzo C D, Ianuzzo S E, Anderson W A
Deborah Research Institute, Browns Mills, New Jersey, USA.
J Card Surg. 1996 Jul-Aug;11(4):293-303. doi: 10.1111/j.1540-8191.1996.tb00053.x.
Dynamic cardiomyoplasty has been shown to result in muscle damage and necrosis. The purpose of this study was to compare the effects of intermittent versus continuous stimulation on the latissimus dorsi muscle (LDM) with and without surgical dissection.
Surgically dissected and nondissected goat LDM were either stimulated continuously (24 hours/day) or intermittently (16 hours on/8 hours off/day) for 60 to 75 days.
The findings show that the continuous stimulation induced the most complete transformation of myosin isoforms and Ca2+ pump isoforms in the nondissected LDM, whereas, intermittent stimulation resulted in less muscle damage in the surgically dissected LDM. Intermittent stimulation of the dissected LDM resulted in larger fiber areas and a lower connective tissue concentration than did the continuous stimulation.
It was concluded that surgically dissected muscle responds differently to electrical stimulation and that intermittent stimulation may result in less damage while transforming the LDM pedicle for use in cardiomyoplasty.
动态心肌成形术已被证明会导致肌肉损伤和坏死。本研究的目的是比较间歇性刺激与持续性刺激对有或无手术剥离的背阔肌（LDM）的影响。
对手术剥离和未剥离的山羊LDM进行持续刺激（每天24小时）或间歇性刺激（每天开16小时/关8小时），持续60至75天。
研究结果表明，持续刺激在未剥离的LDM中诱导了肌球蛋白同工型和Ca2+泵同工型最完全的转变，而间歇性刺激在手术剥离的LDM中导致的肌肉损伤较少。与持续刺激相比，对剥离的LDM进行间歇性刺激导致更大的纤维面积和更低的结缔组织浓度。
得出的结论是，手术剥离的肌肉对电刺激的反应不同，并且在将LDM蒂转化用于心肌成形术时，间歇性刺激可能导致更少的损伤。
