Kashgarian M
Department of Pathology, Yale University School of Medicine, New Haven, Connecticut 06520-8023, USA.
Ren Fail. 1996 Sep;18(5):765-73. doi: 10.3109/08860229609047705.
The renal biopsy plays an important role in the clinical evaluation of patients with lupus erythematosus. From numerous studies of renal biopsies in lupus nephritis, it has become clear that although the renal lesions are quite varied, the pattern of renal involvement correlates with the clinical outcome. The broad spectrum of lesions seen in lupus nephritis has been attributed to individual differences in the immune response in different patients or in the same patient during the course of disease. Classification of lupus nephritis authorized by the World Health Organization has provided a standardized approach to the findings on renal biopsy. This classification combines all of the morphologic modalities of biopsy interpretation including light, immuno-fluorescence, and electron microscopy as well as providing a semiquantitative assessment of activity and chronicity. The clinical correlations utilizing this histologic classifications have demonstrated that the specific nature of the renal histopathology can predict both the acute and long-term outcome of the renal disease in patients with lupus erythematosus and can be useful in determining the management of individual patients.
肾活检在红斑狼疮患者的临床评估中起着重要作用。通过对狼疮性肾炎肾活检的大量研究，已明确尽管肾脏病变多种多样，但肾脏受累模式与临床结局相关。狼疮性肾炎中所见的广泛病变归因于不同患者或同一患者在疾病过程中免疫反应的个体差异。世界卫生组织认可的狼疮性肾炎分类为肾活检结果提供了标准化方法。该分类结合了活检解读的所有形态学方法，包括光镜、免疫荧光和电子显微镜检查，还提供了活动度和慢性度的半定量评估。利用这种组织学分类的临床相关性表明，肾脏组织病理学的具体性质可预测红斑狼疮患者肾脏疾病的急性和长期结局，并且有助于确定个体患者的治疗方案。
