Mishra R C, Singh D N, Mishra T K
A.H. Regional Centre for Cancer Research and Treatment, Orissa, India.
Eur J Surg Oncol. 1996 Oct;22(5):502-4. doi: 10.1016/s0748-7983(96)92969-8.
Squamous cell carcinoma of the buccal mucosa is a common cancer in India. We are referred a large number of locally advanced lesions where curative surgery is still possible. The objective of this study is to determine the role of post-operative radiotherapy in enhancing disease-free survival. Patients with stages III and IV cancer of the buccal mucosa potentially curable by surgery were randomized to surgery only or post-operative radiotherapy. Patients were followed up for 3 years. The clinico-pathological features in both arms were comparable. Disease-free survival at the end of the study was found to be 38% and 68% (P<0.005) respectively. Post-operative radiotherapy was thus seen to improve disease-free survival in squamous cell carcinoma of the buccal mucosa.
颊黏膜鳞状细胞癌在印度是一种常见的癌症。我们接收了大量局部晚期病变患者，对这些患者仍有可能进行根治性手术。本研究的目的是确定术后放疗在提高无病生存率方面的作用。颊黏膜III期和IV期癌症且有可能通过手术治愈的患者被随机分为仅接受手术组或术后放疗组。对患者进行了3年的随访。两组的临床病理特征具有可比性。研究结束时，无病生存率分别为38%和68%（P<0.005）。因此，术后放疗可提高颊黏膜鳞状细胞癌的无病生存率。
