Jarrar K, Amasheh R A, Graef V, Weidner W
Department of Urology, University of Giessen, Germany.
Urol Int. 1996;56(1):16-20. doi: 10.1159/000282801.
In order to clarify the role of 1,25-dihydroxyvitamin-D [1,25-(OH)2-D] in calcium stone formation, correlations between 1,25-(OH)2-D serum levels and levels of calcium, phosphate and uric acid (UA) in serum or urine and between the 1,25-(OH)2-D serum level and age were analyzed in 111 formers of urinary stones (57 Ca stones) and in 44 controls. Furthermore, 1,25-(OH)2-D serum levels as well as levels of Ca, phosphate and UA in serum and urine from formers of different urinary stones and controls were compared. 1,25-(OH)2-D serum levels were determined by a radio-receptor assay based on a calf thymus receptor. 1,25-(OH)2-D serum levels correlated positively with urinary UA excretion in formers of Ca stones and with urinary Ca excretion in formers of Ca stones and controls. In formers of Ca stones urinary Ca excretion was higher and serum phosphate was lower than in controls. 1,25-(OH)2-D serum levels did not differ. 1,25-(OH)2-D serum levels decreased with increasing age in controls, but not in stone formers. Our results show that urinary UA and 1,25-(OH)2-D in serum co-influence Ca stone formation, and they suggest that there is an increased sensitivity to 1,25-(OH)2-D in formers of Ca stones.
为阐明1,25 - 二羟维生素D[1,25-(OH)₂-D]在钙结石形成中的作用，我们分析了111例尿结石患者（57例钙结石患者）和44例对照者血清中1,25-(OH)₂-D水平与血清及尿液中钙、磷和尿酸（UA）水平之间的相关性，以及血清1,25-(OH)₂-D水平与年龄之间的相关性。此外，还比较了不同类型尿结石患者和对照者的血清1,25-(OH)₂-D水平以及血清和尿液中钙、磷和UA水平。血清1,25-(OH)₂-D水平采用基于小牛胸腺受体的放射受体分析法测定。钙结石患者的血清1,25-(OH)₂-D水平与尿UA排泄量呈正相关，与钙结石患者及对照者的尿钙排泄量也呈正相关。钙结石患者的尿钙排泄量高于对照者，血清磷低于对照者。血清1,25-(OH)₂-D水平无差异。对照者的血清1,25-(OH)₂-D水平随年龄增长而降低，但结石患者并非如此。我们的结果表明，尿UA和血清1,25-(OH)₂-D共同影响钙结石的形成，并且提示钙结石患者对1,25-(OH)₂-D的敏感性增加。
