Abdel-Aziz A F, el-Waseef A, Abou el-Fotouh M
Department of Chemistry, Faculty of Science, Mansoura University, Egypt.
Int Urol Nephrol. 1996;28(4):457-64. doi: 10.1007/BF02550950.
The precise relationship between urine composition and stone formation has not yet been completely understood. The object of this work is to study some constituents of the urine in stone formers and normal subjects in a trial to correlate stone formation with urine composition. Urinary levels of oxalic acid, uric acid and phosphate were elevated in oxalate, urate and phosphate stone formers, respectively, while in the urine of mixed stone formers both oxalic and uric acids were increased. Urinary levels of ascorbic acid, citric acid and mucopolysaccharides in all groups of patients were significantly higher than the corresponding control levels. Although oxalic acid, uric acid and phosphate concentrations were high in their respective stones, the concentrations of these constituents were nearly the same in the mixed stones. Also Ca2+ concentration was higher in stones of oxalate and mixed stone formers than in stones of urate and phosphate formers. Exceptionally, magnesium was high in stones of phosphate stone formers. It is recommended that urinary contents of oxalate, urate and phosphate have to be minimized to overcome stone recurrence.
尿液成分与结石形成之间的确切关系尚未完全明了。本研究的目的是对结石患者和正常受试者的尿液中的一些成分进行研究，以尝试将结石形成与尿液成分关联起来。草酸盐、尿酸盐和磷酸盐结石患者的尿液中，草酸、尿酸和磷酸盐水平分别升高，而混合性结石患者的尿液中草酸和尿酸均增加。所有患者组尿液中的抗坏血酸、柠檬酸和粘多糖水平均显著高于相应的对照水平。尽管草酸、尿酸和磷酸盐在各自的结石中浓度较高，但这些成分在混合结石中的浓度几乎相同。此外，草酸盐和混合性结石患者结石中的Ca2+浓度高于尿酸盐和磷酸盐结石患者的结石。例外的是，磷酸盐结石患者的结石中镁含量较高。建议尽量减少尿液中草酸盐、尿酸盐和磷酸盐的含量，以防止结石复发。
