Imamura S I, Takao A, Matsuoka R
Research Division, The Heart Institute of Japan, Tokyo Women's Medical College.
Eur J Clin Invest. 1996 Mar;26(3):240-6. doi: 10.1046/j.1365-2362.1996.141275.x.
The authors examined whether there is any correlation between the regression speed of cardiac beta (V3)-myosin heavy-chain (MHC) isozyme and duration of overload. The results showed that in the right ventricle of a 1-week overloaded group, the loaded ventricular MHC isozyme V3 (29 center dot 0 +/- 5 center dot 0%, P < 0 center dot 05) returned to the control level within 1 week after relief of overload (20 center dot 4 +/- 4 center dot 2%, P = NS), whereas in a 3 week overloaded group (32 center dot 8 +/- 5 center dot 3%, P < 0 center dot 05) it took 10 weeks (36 center dot 6 +/- 8 center dot 6%, P = NS). The left ventricle showed the same tendency as the right ventricle. In sham-operated rats, however, the changes in MHC isozyme V3 in the left ventricle were greater than those in the right ventricle. These results suggest that regression speed of the cardiac MHC isoform, changed by pressure overload, is accompanied by the duration of overload. Furthermore, the right and left ventricles may have different responsiveness to MHC isoform transitions in heart stresses.
作者研究了心脏β（V3）-肌球蛋白重链（MHC）同工酶的回归速度与超负荷持续时间之间是否存在任何相关性。结果显示，在1周超负荷组的右心室中，负荷心室的MHC同工酶V3（29.0±5.0%，P<0.05）在解除超负荷后1周内恢复到对照水平（20.4±4.2%，P=无显著性差异），而在3周超负荷组（32.8±5.3%，P<0.05）中，恢复到对照水平则需要10周（36.6±8.6%，P=无显著性差异）。左心室表现出与右心室相同的趋势。然而，在假手术大鼠中，左心室MHC同工酶V3的变化大于右心室。这些结果表明，压力超负荷改变的心脏MHC同工型的回归速度与超负荷持续时间相关。此外，左右心室在心脏应激中对MHC同工型转变可能具有不同的反应性。
