亚麻胺对血管内皮生长因子引发的毛细血管内皮细胞迁移和增殖的影响。
The effect of linomide on the migration and the proliferation of capillary endothelial cells elicited by vascular endothelial growth factor.
作者信息
Parenti A, Donnini S, Morbidelli L, Granger H J, Ziche M
机构信息
Department of Pharmacology, University of Florence, Italy.
出版信息
Br J Pharmacol. 1996 Oct;119(4):619-21. doi: 10.1111/j.1476-5381.1996.tb15718.x.
Abstract
In order to assess the mechanism of action of the quinoline-3-carboxyamide linomide as an antiangiogenic drug, the effect of linomide was studied in vitro on postcapillary endothelial cells exposed to vascular endothelial growth factor (VEGF). Linomide did not block the spontaneous replication of endothelial cells, but significantly suppressed endothelial cell growth and migration elicited by VEGF. It is concluded that linomide appears to be an effective tool to inhibit VEGF-dependent angiogenesis.
摘要
为评估喹啉-3-羧酰胺类药物利诺胺作为抗血管生成药物的作用机制，研究了利诺胺在体外对暴露于血管内皮生长因子（VEGF）的毛细血管后内皮细胞的影响。利诺胺并不阻断内皮细胞的自发增殖，但能显著抑制由VEGF引发的内皮细胞生长和迁移。得出的结论是，利诺胺似乎是抑制VEGF依赖性血管生成的有效工具。
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