Oligodendroglial sheath lengths in developing rat ventral funiculus and corpus callosum.

The lengths of uncompacted and partly compacted oligodendroglial sheaths in the developing rat spinal cord (SC) ventral funiculus (ages F19 and F21) and corpus callosum (CC; ages P12 and P17) were studied by serial section electron microscopy. The average newly formed uncompacted sheath is 21 and 33 microns long in the SC (F19) and CC (P12), respectively, many being less than 10 microns. In these early series, approximately 2/3 of the analysed axon length is unensheathed. The average partly compacted sheath is 102 and 69 microns long in the SC (F21) and CC (P17), respectively. Here, about 1/3 of the examined axon length is unensheathed. These results suggest that oligodendroglial sheaths initially are very short, and that they elongate actively before and during compaction. The limited unensheathed space along these axons indicate that some early sheaths must be eliminated.