Parnas B L, Durley R C, Rhoden E E, Kilpatrick B F, Makkar N, Thomas K E, Smith W G, Corley D G
Searle Research and Development, Monsanto Company, St. Louis, Missouri 63198, USA.
J Nat Prod. 1996 Oct;59(10):962-4. doi: 10.1021/np9603986.
The novel amino acid 8(S)-amino-2(R)-methyl-7-oxononanoic acid (1) was isolated from the soil-borne microorganism Streptomyces diastaticus during our screening for inhibitors of leukotriene-A4 hydrolase (LTA4H), a requisite enzyme in the biosynthesis of the potent inflammatory mediator leukotriene-B4 (LTB4). The structure of 1 was determined by detailed spectroscopic analyses and is related to 7-keto-8-aminopelargonic acid (2), a biosynthetic precursor of biotin. The relative potency of 1 (LTA4H IC50 = 0.6 microM) warranted further biological studies.
