Albinsson A, Andersson G, Andersson K, Vega-Matuszczyk J, Larsson K
Pharmacia AB, Lund, Sweden.
Behav Brain Res. 1996 Oct;80(1-2):57-63. doi: 10.1016/0166-4328(96)00020-4.
Lesions were produced in the median and the dorsal raphe nuclei of the rat, and the effects of these injuries on various behaviors were studied. The median raphe lesions had facilitatory effects on the male rat sexual behavior, as evidenced by a decrease in the number of intromissions prior to ejaculation, as well as shortening of the ejaculation latency and the postejaculatory interval. No effects were seen on the masculine sexual behavior after lesions in the dorsal raphe nucleus. The median raphe lesions drastically increased the locomotory activity whereas the dorsal raphe lesions did not. Treatment with FG5893, a 5-HT1A agonist/5-HT2A receptor antagonist, increased the locomotor activity of the dorsal-raphe-lesioned rats but did not affect the median-raphe-lesioned animals. These results suggest that the dorsal and the median raphe nuclei play different roles in the neural regulation of the sexual behavior and locomotor activity of the male rat. The median raphe nucleus appears to exert a modulatory influence upon these behaviors, which probably is mediated by serotonergic neural pathways.
在大鼠的中缝正中核和中缝背核制造损伤，并研究这些损伤对各种行为的影响。中缝正中核损伤对雄性大鼠性行为有促进作用，表现为射精前插入次数减少，射精潜伏期和射精后间隔缩短。中缝背核损伤后未观察到对雄性性行为有影响。中缝正中核损伤极大地增加了运动活性，而中缝背核损伤则没有。用5-HT1A激动剂/5-HT2A受体拮抗剂FG5893治疗，增加了中缝背核损伤大鼠的运动活性，但对中缝正中核损伤动物没有影响。这些结果表明，中缝背核和中缝正中核在雄性大鼠性行为和运动活性的神经调节中发挥不同作用。中缝正中核似乎对这些行为发挥调节作用，这可能是由5-羟色胺能神经通路介导的。
