Isolated aplasia of the anterior pituitary gland with unusual associations.

A male infant was found to have cleft lip and palate with micropenis at birth. He suffered recurrent episodes of hypoglycaemia in the first 3 days. CT scan showed possible incomplete division of the frontal lobes and endocrinological investigations confirmed hypopituitarism. He developed renal and respiratory failure and died at the age of 10 days. Post mortem showed an absent adenohypophysis, an intact neurohypophysis, absent olfactory tracts and polysplenia.