Ramirez V D, Zheng J
Department of Molecular and Integrative Physiology, University of Illinois, Urbana, USA.
Front Neuroendocrinol. 1996 Oct;17(4):402-39. doi: 10.1006/frne.1996.0011.
In this review we discuss evidence indicating the existence of specific binding receptor sites for progesterone (P), estrogen (E), and testosterone (T) in neural membranes. The review starts with the methodological approaches for studying receptor binding sites in neural membranes. Second, we examine the physiological and biochemical data supporting the concept of cognate membrane receptors for P, E, and T, the so-called mPR, mER, and mTR. Last, we present an overview emphasizing the concept of continuity of action of steroids on cells from the outer surface to nuclear events.
在本综述中，我们讨论了表明神经膜中存在孕酮（P）、雌激素（E）和睾酮（T）特异性结合受体位点的证据。综述首先介绍了研究神经膜中受体结合位点的方法学。其次，我们审视了支持P、E和T同源膜受体概念的生理和生化数据，即所谓的膜孕酮受体（mPR）、膜雌激素受体（mER）和膜睾酮受体（mTR）。最后，我们进行了概述，强调了类固醇从细胞外表面到核事件作用连续性的概念。
