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[多杀巴斯德菌抗原结构的测定:疫苗的制备]

[Determination of antigen structures of Pasteurella multocida: the preparation of vaccines].

作者信息

Desmettre P, Valette L

出版信息

Dev Biol Stand. 1978;41:401-9.

PMID:89055
Abstract

The discovery of the role played by somatic antigens of the Pasteurella multocida A and D capsular types in the immunization of susceptible species makes it necessary to type the somatic antigens of the isolated strains prior to any action to induce active or passive immunity. Only immunoprecipitation in gel was chosen out of the various typing techniques proposed, and a correlation was established between the capsular types (according to Carter), somatic types (according to Namioka) and types determined by immunoprecipitation in gel (according to Heddleston). Parallel to this, the same technique was developed for strains of Pasteurella multocida B and E capsular types, and the immunogenicity of these capsular antigens was proven.

摘要

多杀性巴氏杆菌A和D荚膜型菌体抗原在易感物种免疫中所起作用的发现,使得在采取任何诱导主动或被动免疫的行动之前,有必要对分离菌株的菌体抗原进行分型。在提出的各种分型技术中,仅选用了凝胶免疫沉淀法,并在荚膜型(根据卡特分型)、菌体型(根据波冈分型)和凝胶免疫沉淀法确定的类型(根据赫德尔斯顿分型)之间建立了相关性。与此同时,针对多杀性巴氏杆菌B和E荚膜型菌株也开发了相同的技术,并证明了这些荚膜抗原的免疫原性。

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