Wisborg K, Sapthavichaikul S, Skovsted P
Can Anaesth Soc J. 1977 Jul;24(4):505-13. doi: 10.1007/BF03005455.
We have studied the effects of propanidid on preganglionic cervical sympathetic nervous activity, arterial pressure, pulse rate and barostatic reflexes of the cat. Normal, hypertensive, baroreceptor denervated and decerebrate animals with sectioned vagal nerves were studied. On the basis of our findings it is concluded that propanidid exerts its depressant action on the cardiovascular system directly. Central circulatory control mechanisms are essentially unaffected. The depression of arterial pressure caused by propanidid is moderated by two compensatory mechanisms: normal barostatic reflexes causing an increased sympathetic tone in response to hypotension and a vagolytic action of propanidid.
我们研究了丙泮尼地对猫颈上交感神经节前神经活动、动脉血压、心率及压力感受性反射的影响。研究对象包括正常、高血压、压力感受器去神经支配及迷走神经切断的去大脑动物。根据我们的研究结果得出结论：丙泮尼地直接对心血管系统发挥抑制作用。中枢循环控制机制基本未受影响。丙泮尼地引起的动脉血压降低受到两种代偿机制的调节：正常的压力感受性反射在低血压时引起交感神经张力增加，以及丙泮尼地的抗迷走神经作用。
