Said S M, Yeh T L, Greenwood R S, Whitt J K, Tupler L A, Krishnan K R
Department of Neurology, University of North Carolina School of Medicine, Durham 27710, USA.
Neuroreport. 1996 Aug 12;7(12):1941-4. doi: 10.1097/00001756-199608120-00015.
Volumes of cerebral gray and white matter were measured in 22 children with neurofibromatosis type 1 (NF1) and in 20 controls. Judgment of Line Orientation (JLO) and the Developmental Test of Visual-Motor Integration (DTVMI) were administered to 16 of the NF1 patients. General linear models analysis of covariance revealed significantly larger brain volumes in NF1 children than in controls, particularly in white matter, and particularly in girls. JLO and DTVMI performance were positively related to right-hemisphere gray-matter volume. The results implicate a failure of growth control in NF1, leading to aberrant neurodevelopment. Our findings also suggest a basis for refined understanding of learning disabilities, which are a prominent feature of NF1.
对22名1型神经纤维瘤病（NF1）患儿和20名对照儿童的脑灰质和白质体积进行了测量。对16名NF1患者进行了线方向判断（JLO）和视觉运动整合发育测试（DTVMI）。协方差的一般线性模型分析显示，NF1患儿的脑体积明显大于对照组，尤其是白质，女孩更为明显。JLO和DTVMI表现与右半球灰质体积呈正相关。结果表明NF1存在生长控制失败，导致神经发育异常。我们的研究结果还为深入理解学习障碍提供了依据，学习障碍是NF1的一个突出特征。
