Rath S A, Klein H J, Richter H P
Department of Neurosurgery, University of Ulm, Günzburg, Germany.
Neurosurgery. 1996 Nov;39(5):933-8; discussion 938-40. doi: 10.1097/00006123-199611000-00010.
To evaluate the indication of subsequent operations after failed microvascular decompression (MVD) for the treatment of trigeminal neuralgia, the intraoperative findings and long-term results of 16 subsequent operations are reported.
Subsequent exploration of the posterior fossa was performed for lack of pain relief (3 patients) and recurrent neuralgia (13 patients) after an average of 17 months (range, 4-62 mo). In all patients, typical arterial compression patterns at the root entry zone of the trigeminal nerve were found in the first procedure. The mean follow-up period after subsequent operation was 90 months (range, 78-104 mo).
New arterial neurovascular conflicts were found in nine patients. After subsequent MVD procedures, seven patients were pain-free (with one recurrence after 6 mo), one had constant marked relief, and one was unchanged. Second exploration revealed no abnormalities in the other seven patients who experienced continued or recurrent pain; only careful neurolysis of the trigeminal nerve was performed in those patients. Initially, all seven patients obtained complete pain relief, but two experienced late recurrences after 64 and 68 months, respectively. Thus, subsequent operations failed in all 4 patients who had undergone prior destructive procedures but were successful in those 12 patients who had undergone only previous MVD. Two patients developed severe sequelae, and the other nine had minor complications, especially permanent (four patients) or transitory (three patients) ipsilateral trigeminal hypoesthesia.
Subsequent MVD seems to have good long-term results. However, because of the significantly high incidence of complications, the indication for subsequent operations should be restricted to younger patients to avoid destructive procedures. In general, glycerol rhizolysis or radiofrequency rhizotomy may be the treatment of choice after failed MVD.
为评估微血管减压术(MVD)治疗三叉神经痛失败后后续手术的适应证,报告16例后续手术的术中发现及长期结果。
因平均17个月(范围4 - 62个月)后疼痛未缓解(3例患者)或神经痛复发(13例患者)而进行后颅窝再次探查。所有患者在首次手术中均发现三叉神经根入区典型的动脉压迫模式。后续手术后的平均随访期为90个月(范围78 - 104个月)。
9例患者发现新的动脉神经血管冲突。后续进行MVD手术后,7例患者疼痛消失(1例在6个月后复发),1例疼痛显著持续缓解,1例无变化。二次探查发现,另外7例持续疼痛或复发疼痛的患者无异常;这些患者仅对三叉神经进行了仔细的神经松解术。最初,所有7例患者疼痛完全缓解,但分别在64个月和68个月后有2例出现晚期复发。因此,先前接受过破坏性手术的4例患者后续手术均失败,而仅接受过MVD手术的12例患者手术成功。2例患者出现严重后遗症,其他9例有轻微并发症,尤其是永久性(4例患者)或暂时性(3例患者)同侧三叉神经感觉减退。
后续MVD似乎有良好的长期效果。然而,由于并发症发生率显著较高,后续手术的适应证应限于年轻患者以避免采用破坏性手术。一般来说,甘油神经根切断术或射频神经根切断术可能是MVD失败后的首选治疗方法。