一种99mTc与三（羟甲基）膦（THP）络合物的体外和体内特性研究

In vitro and in vivo characterization of a 99mTc complex with tris(hydroxymethyl)phosphine (THP).

作者信息

Berning D E, Katti K V, Singh P R, Higgenbotham C, Reddy V S, Volkert W A

机构信息

Department of Chemistry, University of Missouri, Columbia, USA.

出版信息

Nucl Med Biol. 1996 Jul;23(5):617-22. doi: 10.1016/0969-8051(96)00058-3.

DOI:10.1016/0969-8051(96)00058-3

PMID:8905826

Abstract

The water-soluble, monophosphine ligand tris(hydroxymethyl)phosphine (THMP) was complexed with 99mTc. The 99mTc-THMP was formed in high radiochemical purity by simply mixing 99mTcO4- with THMP over a wide pH range. In vitro and in vivo studies indicated the complex to be highly stable under the respective conditions. HPLC analysis indicated a singular species with a retention time identical to the known [ReO2(THMP)4]1 complex. Results show that the hydroxymethylphosphine functionality is attractive for use in designing new 99mTc radiopharmaceuticals.

摘要

水溶性单膦配体三（羟甲基）膦（THMP）与99mTc形成络合物。通过在很宽的pH范围内简单地将高锝酸盐（99mTcO4-）与THMP混合，以高放射化学纯度形成了99mTc-THMP。体外和体内研究表明该络合物在各自条件下高度稳定。高效液相色谱分析表明存在一种单一物质，其保留时间与已知的[ReO2(THMP)4]1络合物相同。结果表明，羟甲基膦官能团对于设计新型99mTc放射性药物具有吸引力。