Kublickas M, Lunell N O, Nisell H, Westgren M
Department of Obstetrics and Gynecology, Karolinska Institutet, Huddinge University Hospital, Sweden.
Acta Obstet Gynecol Scand. 1996 Sep;75(8):715-9. doi: 10.3109/00016349609065733.
To investigate the effect of normal pregnancy and hypertensive disorders of pregnancy on the maternal renal artery Doppler blood flow velocity indices.
The patient material consisted of 30 normal pregnant women, 29 women with pregnancy induced hypertension, 43 women with preeclampsia and 22 pregnant women with chronic hypertension. Blood flow velocities in the segmental renal arteries from the right kidney were analysed by pulsed and color Doppler. The systolic/diastolic (s.d.) ratio, resistance index (RI) and pulsatility index (PI) were used for Doppler waveform analysis.
In all of the groups of hypertensive pregnant women renal artery Doppler indices were significantly lower compared to the normal pregnant women group. There was a significant negative relationship between renal artery PI and mean arterial pressure in the preeclampsia group and in the chronic hypertension group.
The present results demonstrate that the mechanism of renal autoregulation in preeclampsia might be altered, leaving glomerulus unprotected from increased blood pressure. It seems that the concept of renal vasoconstriction in preeclampsia might be disputed and needs further investigation.
探讨正常妊娠及妊娠高血压疾病对孕妇肾动脉多普勒血流速度指标的影响。
研究对象包括30例正常孕妇、29例妊娠期高血压孕妇、43例子痫前期孕妇和22例慢性高血压孕妇。采用脉冲多普勒和彩色多普勒分析右肾段动脉的血流速度。利用收缩期/舒张期（s.d.）比值、阻力指数（RI）和搏动指数（PI）进行多普勒波形分析。
与正常孕妇组相比，所有高血压孕妇组的肾动脉多普勒指标均显著降低。子痫前期组和慢性高血压组中，肾动脉PI与平均动脉压之间存在显著负相关。
目前的结果表明，子痫前期肾自动调节机制可能发生改变，使肾小球无法免受血压升高的影响。子痫前期肾血管收缩的概念似乎存在争议，需要进一步研究。
