Biel M A
Minneapolis Ear, Nose, and Throat Clinic, Minn, USA.
Arch Otolaryngol Head Neck Surg. 1996 Nov;122(11):1261-5. doi: 10.1001/archotol.1996.01890230105018.
To demonstrate the feasibility of adjuvant intraoperative photodynamic therapy in the treatment of large, infiltrating, recurrent carcinomas of the head and neck.
A nonrandomized trial involving 5 patients treated with intraoperative adjuvant photodynamic therapy with 29-month follow-up.
A tertiary care referral center in a private practice setting.
Five patients with massive, recurrent, infiltrating squamous cell carcinomas of the head and neck and skull base.
Photodynamic therapy was used as an adjuvant intraoperative treatment after resection of tumors.
Time of survival after treatment without recurrence of disease.
Four of the 5 patients have remained free of recurrent disease without complications up to 24 months after treatment.
Adjuvant intraoperative photodynamic therapy may improve cure rates in patients with recurrent head and neck malignancies by providing larger tumor-free margins of resection, while preserving normal structures.
证明术中辅助光动力疗法治疗头颈部大型浸润性复发性癌的可行性。
一项非随机试验，涉及5例接受术中辅助光动力疗法治疗的患者，随访29个月。
一家私人执业环境中的三级医疗转诊中心。
5例患有头颈部和颅底巨大、复发性浸润性鳞状细胞癌的患者。
光动力疗法在肿瘤切除后用作术中辅助治疗。
治疗后无疾病复发的生存时间。
5例患者中有4例在治疗后长达24个月无疾病复发且无并发症。
术中辅助光动力疗法可通过提供更大的无瘤切除边缘，同时保留正常结构，提高复发性头颈部恶性肿瘤患者的治愈率。
