维甲酸分化的神经母细胞瘤细胞中花生四烯酸的合成与脂质代谢

Arachidonic acid synthesis and lipid metabolism in retinoic acid-differentiated neuroblastoma cells.

作者信息

Petroni A, Blasevich M, La Spada P, Papini N, Galli C

机构信息

Institute of Pharmacological Sciences, University of Milan, Italy.

出版信息

J Lipid Mediat Cell Signal. 1996 Sep;14(1-3):39-44. doi: 10.1016/0929-7855(96)00506-8.

DOI:10.1016/0929-7855(96)00506-8

PMID:8906543

Abstract

SK-N-BE cells were differentiated (D) to neurons with retinoic acid. Total n-6 polyunsaturated fatty acids (PUFA), especially arachidonic acid (AA), were increased in D versus ND cells. AA synthesis from linoleic acid (LA) and phospholipid (PL) synthesis from glycerol were initially elevated, whereas both processes were reduced approaching differentiation. At this stage, the incorporation of glycerol in triglycerides was enhanced. Formation of long chain PUFA and synthesis of acceptors (PL) for esterification, during RA-induced SK-N-BE differentiation, appear to be associated.

摘要

SK-N-BE细胞用视黄酸分化为神经元。与未分化（ND）细胞相比，分化（D）细胞中的总n-6多不饱和脂肪酸（PUFA），尤其是花生四烯酸（AA）增加。从亚油酸（LA）合成AA以及从甘油合成磷脂（PL）最初升高，而在接近分化时这两个过程都减少。在此阶段，甘油掺入甘油三酯的过程增强。在视黄酸诱导的SK-N-BE分化过程中，长链PUFA的形成与酯化受体（PL）的合成似乎相关。