Shimizu T, Mori M, Bito H, Sakanaka C, Tabuchi S, Aihara M, Kume K
Department of Biochemistry, Faculty of Medicine, University of Tokyo, Japan.
J Lipid Mediat Cell Signal. 1996 Sep;14(1-3):103-8. doi: 10.1016/0929-7855(96)00515-9.
Platelet-activating factor (PAF) receptor and somatostatin receptor (SSTR4) were cloned, and their primary structures were identified. They are both highly expressed in the rat hippocampus. When expressed in Chinese hamster ovary cells, these receptors activated mitogen-activated protein (MAP) kinase cascade and phospholipase A2. Arachidonic acid or its derivatives, thus produced by the activation of these receptors may play some roles in synaptic transmission and synaptic plasticity.
血小板活化因子（PAF）受体和生长抑素受体（SSTR4）被克隆出来，并确定了它们的一级结构。它们在大鼠海马体中均高度表达。当在中华仓鼠卵巢细胞中表达时，这些受体会激活丝裂原活化蛋白（MAP）激酶级联反应和磷脂酶A2。这些受体激活后产生的花生四烯酸或其衍生物可能在突触传递和突触可塑性中发挥某些作用。
