Acute regulation of the receptor-mediated phosphoinositide signal transduction pathway.

It is apparent that the phosphoinositide signalling pathway is subject to a variety of regulatory features which will ultimately dictate the magnitude and profile of cellular responses to agonist occupation of PIC-linked receptors. Our understanding of these mechanisms is far from complete but will be crucial in revealing both the specificity of receptor signalling and the integration of signals arising from the potentially wide variety of metabotropic and ionotropic receptors on individual cells.