Chonan O, Takahashi R, Kado S, Nagata Y, Kimura H, Uchida K, Watanuki M
Yakult Central Institute for Microbiological Research, Kunitachi, Japan.
J Nutr Sci Vitaminol (Tokyo). 1996 Aug;42(4):313-23. doi: 10.3177/jnsv.42.313.
The effects of calcium gluconate on the utilization of magnesium and nephrocalcinosis in male Wistar rats made magnesium-deficient by adding excess dietary phosphorus (1.195 g of phosphorus/100 g of diet) and calcium (1.04 g of calcium/100 g of diet) were compared with the effects of calcium carbonate. The effects of dietary magnesium concentration on the magnesium status and nephrocalcinosis were also examined. Adding excess dietary phosphorus and calcium decreased the apparent magnesium absorption ratios and the concentrations of magnesium in the serum and femur and increased the deposition of calcium in the kidney, and the low magnesium condition (0.024 g of magnesium/100 g of diet) aggravated the deposition of calcium and the low magnesium status. The apparent magnesium absorption ratios and femur magnesium concentration in the rats fed a calcium gluconate diet (an equimolar mixture of calcium gluconate and calcium carbonate was used as a source of calcium) were significantly higher than in the rats fed a calcium carbonate diet (only calcium carbonate was used as a source of calcium), irrespective of dietary magnesium concentration. Dietary calcium gluconate lessened the accumulation of calcium in the kidney and increased the serum magnesium concentration compared with dietary calcium carbonate, when the rats were fed the normal magnesium diet (0.049 g of magnesium/100 g of diet) but not the low magnesium diet. We speculate that the increased utilization of magnesium by feeding the calcium gluconate diet to a limited extent prevented the low magnesium status and the severity of nephrocalcinosis caused by adding excess dietary phosphorus and calcium.
将葡糖酸钙对雄性Wistar大鼠镁利用及肾钙质沉着症的影响，与碳酸钙的影响进行了比较。这些雄性Wistar大鼠通过添加过量膳食磷（1.195克磷/100克饲料）和钙（1.04克钙/100克饲料）而导致镁缺乏。同时还研究了膳食镁浓度对镁状态和肾钙质沉着症的影响。添加过量膳食磷和钙会降低表观镁吸收比率以及血清和股骨中的镁浓度，并增加肾脏中钙的沉积，而低镁状况（0.024克镁/100克饲料）会加重钙的沉积和低镁状态。无论膳食镁浓度如何，喂食葡糖酸钙饲料（使用葡糖酸钙和碳酸钙的等摩尔混合物作为钙源）的大鼠的表观镁吸收比率和股骨镁浓度均显著高于喂食碳酸钙饲料（仅使用碳酸钙作为钙源）的大鼠。当大鼠喂食正常镁饲料（0.049克镁/100克饲料）而非低镁饲料时，与膳食碳酸钙相比，膳食葡糖酸钙减少了肾脏中钙的积累并提高了血清镁浓度。我们推测，通过喂食葡糖酸钙饲料在一定程度上提高镁的利用率，可预防因添加过量膳食磷和钙而导致的低镁状态和肾钙质沉着症的严重程度。
