Yoonessi M, Hart W R
Cancer. 1977 Aug;40(2):898-906. doi: 10.1002/1097-0142(197708)40:2<898::aid-cncr2820400246>3.0.co;2-x.
This study is a clinicopathologic evaluation of seven patients with endometrial stromal sarcoma of pure homologous type. Histologic distinction from endometrial stromatosis was based on the presence of high mitotic activity and nuclear anaplasia. One sarcoma appeared to have originated from invasive stromatosis. All patients died within 27 months although the tumor was judged to have been confined to the uterus at the time of hysterectomy in five patients. The aggressive clinical behavior and high mortality rate documented in this and other studies indicate that stromal sarcoma should be distinguished from the better differentiated and more indolent endometrial stromal tumor known as stromatosis or endolymphatic stromal myosis. It is suggested that surgery be supplemented by irradiation and/or chemotherapy as primary treatment for stromal sarcoma in view of its dismal prognosis.
本研究是对7例纯同源型子宫内膜间质肉瘤患者的临床病理评估。与子宫内膜间质增生的组织学鉴别基于高有丝分裂活性和核间变的存在。1例肉瘤似乎起源于侵袭性间质增生。尽管5例患者在子宫切除时肿瘤被判定局限于子宫内，但所有患者均在27个月内死亡。本研究及其他研究记录的侵袭性临床行为和高死亡率表明，间质肉瘤应与分化较好、生长较缓慢的子宫内膜间质肿瘤（即间质增生或淋巴管内间质肌病）相区分。鉴于其预后不佳，建议对间质肉瘤的主要治疗采用手术联合放疗和/或化疗。
