苯并(a)芘衍生的邻二醇环氧化物诱导哺乳动物细胞的恶性转化和诱变。
Malignant transformation and mutagenesis in mammalian cells induced by vicinal diol-epoxides derived from benzo(a)pyrene.
作者信息
Marquardt H, Baker S, Grover P L, Sims P
出版信息
Cancer Lett. 1977 Jul;3(1-2):31-6. doi: 10.1016/s0304-3835(77)93906-4.
Benzo[a] pyrene and the syn- and anti-isomers of the 7,8-diol 9,10-oxide and of the 9,10-diol 7,8-oxide derived from this hydrocarbon have been tested for their abilities to induce malignant transformation in M2 mouse fibroblasts and mutagenesis in V79 Chinese hamster cells. The anti-isomer of the 7,8-diol 9,10-oxide induced more mutations and transformation than did the other three vicinal diol-epoxides. The two 9,10-diol 7,8-oxides were moderately mutagenic but did not induce any transformation. In contrast, benzo[a]-pyrene induced transformation in M2 fibroblasts but was not mutagenic in the V79 cells.
对苯并[a]芘及其由该碳氢化合物衍生的7,8 - 二醇 - 9,10 - 环氧化物和9,10 - 二醇 - 7,8 - 环氧化物的顺式和反式异构体进行了测试，以考察它们在M2小鼠成纤维细胞中诱导恶性转化以及在V79中国仓鼠细胞中诱导诱变的能力。7,8 - 二醇 - 9,10 - 环氧化物的反式异构体比其他三种邻位二醇环氧化物诱导更多的突变和转化。两种9,10 - 二醇 - 7,8 - 环氧化物具有中等程度的诱变性，但未诱导任何转化。相比之下，苯并[a]芘在M2成纤维细胞中诱导转化，但在V79细胞中不具有诱变性。
Zotero 插件