Orsenigo M N, Tosco M, Faelli A
Dipartimento di Fisiologia e Biochimica Generali, Universita di Milano, Italy.
Cell Biochem Funct. 1996 Mar;14(1):69-73. doi: 10.1002/cbf.648.
The jejunal basolateral Cl/HCO3 exchanger is modulated by two Na-dependent regulatory sites located on the inner and outer membrane surfaces. The aim of this work was to focus on the interaction between the anion exchanger and intracellular or extracellular sodium. Uptake studies, performed using basolateral membrane vesicles, provided kinetic parameters as a function of outside or inside Na concentration. The intracellular Na-sensitive modifier site seems to be primarily involved in the modulation of the Cl/HCO3 exchanger.
空肠基底外侧的Cl⁻/HCO₃⁻交换体受位于内膜和外膜表面的两个钠依赖性调节位点调控。本研究旨在聚焦阴离子交换体与细胞内或细胞外钠之间的相互作用。使用基底外侧膜囊泡进行的摄取研究给出了作为细胞外或细胞内钠浓度函数的动力学参数。细胞内钠敏感修饰位点似乎主要参与Cl⁻/HCO₃⁻交换体的调节。
