大鼠穹窿海马伞横断或用192 IgG-皂草素进行选择性免疫损伤后内侧隔核中胆碱乙酰转移酶的活性
Activity of choline acetyltransferase in the rat medial septal nucleus following fimbria-fornix transection or selective immunolesioning with 192 IgG-saporin.
作者信息
Hage B, Frotscher M, Naumann T
机构信息
Institute of Anatomy, University of Freiburg, Germany.
出版信息
Neurosci Lett. 1996 Feb 23;205(2):119-22. doi: 10.1016/0304-3940(96)12392-2.
Changes in the biochemical activity of choline acetyltransferase in the medial septal nucleus, diagonal band and hippocampus were determined following bilateral fimbria-fornix transection or selective immunolesioning of cholinergic septohippocampal neurons with 192 IgG-saporin. Following axotomy, choline acetyltransferase activity in the medial septal nucleus not only persisted but increased much above control values 6 months postlesion, confirming that many cholinergic neurons survive the transection of their axons. In contrast, immunolesioning led to a significant decrease in enzyme activity in the medial septal nucleus corresponding to the selective loss of septal cholinergic neurons in this lesion paradigm.
在双侧穹窿海马伞横断或用192 IgG-皂草素对胆碱能隔海马神经元进行选择性免疫损伤后，测定内侧隔核、斜角带和海马中胆碱乙酰转移酶的生化活性变化。轴突切断后，内侧隔核中的胆碱乙酰转移酶活性不仅持续存在，而且在损伤后6个月增加到远高于对照值，证实许多胆碱能神经元在其轴突横断后存活下来。相比之下，在这种损伤模式中，免疫损伤导致内侧隔核中酶活性显著降低，这与隔区胆碱能神经元的选择性丧失相对应。
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