Kinetics of n-butyl alcohol and m-xylene in blood during single and combined inhalation exposure in rats.

The levels of m-xylene and n-butyl alcohol in blood of rats during single and combined inhalation exposure to m-xylene and n-butyl alcohol at the concentrations of 100 + 100 ppm were investigated. We found that levels of n-butyl alcohol and m-xylene in blood of animals during single exposure did not differ as compared to coexposure. It has been shown that less than additive neurotoxic and irritating respiratory tract effects of m-xylene and n-butyl alcohol mixture, observed earlier under acute and subchronic inhalation study, cannot be explained by their metabolic interaction.