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放射性铯向绵羊组织转移的修正动态模型的开发与测试

Development and testing of a revised dynamic model of radiocaesium transfer to sheep tissues.

作者信息

Crout N M, Beresford N A, Howard B J, Mayes R W, Assimakopoulos P A, Vandecasteele C M

机构信息

Department of Physiology and Environmental Science, University of Nottingham, Sutton Bonington, UK.

出版信息

Radiat Environ Biophys. 1996 Feb;35(1):19-24. doi: 10.1007/BF01211238.

DOI:10.1007/BF01211238
PMID:8907640
Abstract

The model of radiocaesium transfer to sheep presented by Galer et al. provides reliable predictions only for sheep of a similar body weight to those used in the development of the model (approximately 30 kg). To extend the applicability of the model, it was necessary to re-parameterise it in terms of activity concentrations in tissues rather than total activities within them (although for gut compartments the use of activity has been retained). The rate coefficients for the new model have been estimated by fitting the model to the data used by Galer et al. which was derived from a single "calibration" experiment. The new model was found to account for 94% of the observed variation in the data (n = 42), a result similar to that obtained by Galer et al. The model has also been tested against data not used in its development but obtained from four separate experiments undertaken by three different laboratories. Good agreement between the predictions of the new model and observations was found for most circumstances and for several breeds of sheep with different body weights. It is concluded that the new model provides a useful dynamic description of radiocaesium transfers to the tissues of sheep of different breeds and under different contamination scenarios.

摘要

加勒等人提出的放射性铯向绵羊体内转移的模型,仅对与模型开发中所用绵羊体重相似(约30千克)的绵羊能提供可靠预测。为扩大该模型的适用性,有必要根据组织中的活度浓度而非组织内的总活度对其重新进行参数化(不过对于肠道隔室,仍保留了活度的使用)。新模型的速率系数是通过将模型与加勒等人使用的数据拟合来估算的,这些数据源自一项单一的“校准”实验。结果发现,新模型能够解释数据中94%的观测变化(n = 42),这一结果与加勒等人所得结果相似。该模型还针对未用于其开发但取自三个不同实验室进行的四项独立实验的数据进行了测试。在大多数情况下,对于几种不同体重的绵羊品种,新模型的预测与观测结果之间都达成了良好的一致性。结论是,新模型为不同品种绵羊在不同污染情景下放射性铯向其组织的转移提供了有用的动态描述。

相似文献

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本文引用的文献

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ECOSYS-87: a dynamic model for assessing radiological consequences of nuclear accidents.
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Transport of radiocaesium from a sheep's diet to its tissues.放射性铯从绵羊的食物到其组织的转运。
Sci Total Environ. 1993 Aug 15;136(1-2):1-11. doi: 10.1016/0048-9697(93)90292-e.
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The comparative metabolism of strontium, calcium and cesium in deer and sheep.鹿和羊体内锶、钙和铯的比较代谢
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Determination of the transfer of cesium and iodine from feed into domestic animals.测定铯和碘从饲料向家畜体内的转移情况。
Sci Total Environ. 1989 Sep;85:329-38. doi: 10.1016/0048-9697(89)90332-x.
5
Radiocaesium metabolism in pregnant ewes and their progeny.怀孕母羊及其后代体内的放射性铯代谢
Sci Total Environ. 1989 Sep;85:213-23. doi: 10.1016/0048-9697(89)90320-3.