Martin K, Stevenson J C, Crawford M H, Everson P M, Schanfield M S
Department of Anthropology, Western Washington University, Bellingham, WA 98225, USA.
Hum Biol. 1996 Feb;68(1):45-62.
Anabaptist history is a chronicle of repeated migrations, fissions, and fusions of various subgroups. The effects of these events should be evident in the population biology of the Anabaptist groups. No prior genetic studies have included the polymorphic and highly informative immunoglobulin markers. Here, 685 serum samples representing 1 Amish and 3 Mennonite community samples (7 congregations) were studied for immunoglobulin allotypes. The haplotypes IGHGF B, IGHGA,Z G, and IGHGA,X,Z G range in frequency from 0.542 to 0.765, 0.123 to 0.290, and 0.075 to 0.170, respectively. IGK1 frequencies range from 0.035 to 0.077. All frequencies are within expected ranges for central and western European population samples. There was considerable intergroup variability among the Anabaptist samples that was statistically significant (chi29 = 22.63, 0.005 < p < 0.01). Principal component analyses, including the immunoglobulin allotype frequencies and published data on ABO, MN, and Rhesus (Dd) markers, demonstrate that the Mennonite congregation samples with close historical ties group together and are distinct from the Amish and Meridian congregation samples.
再洗礼派的历史是一部关于各个亚群体反复迁徙、分裂和融合的编年史。这些事件的影响在再洗礼派群体的群体生物学中应该是显而易见的。以前没有基因研究纳入多态且信息丰富的免疫球蛋白标记物。在这里，对代表1个阿米什社区样本和3个门诺派社区样本（7个教会）的685份血清样本进行了免疫球蛋白同种异型研究。单倍型IGHGF B、IGHGA,Z G和IGHGA,X,Z G的频率范围分别为0.542至0.765、0.123至0.290和0.075至0.170。IGK1的频率范围为0.035至0.077。所有频率都在中欧和西欧人群样本的预期范围内。再洗礼派样本之间存在相当大的组间变异性，具有统计学意义（卡方9 = 22.63，0.005 < p < 0.01）。主成分分析，包括免疫球蛋白同种异型频率以及关于ABO、MN和恒河猴（Dd）标记物的已发表数据，表明具有密切历史联系的门诺派教会样本聚集在一起，与阿米什和子午线教会样本不同。
