甲状腺过氧化物酶和载脂蛋白B基因的连锁不平衡研究。
Linkage disequilibrium studies in the thyroid peroxidase and apolipoprotein B genes.
作者信息
De Benedictis G, Falcone E, Ruffolo R, Spadafora P, Carotenuto L
机构信息
Department of Cell Biology, University of Calabria, Rende, Italy.
出版信息
Hum Biol. 1996 Feb;68(1):147-54.
Linkage disequilibria in the apolipoprotein B (APOB) gene (EcoRI RFLP/3' APOB VNTR) and in the thyroid peroxidase (TPO) gene (AcyI RFLP/TPO VNTR) were investigated in a sample of 100 individuals from southern Italy. By recoding multiallelic data as diallelic data, each RFLP-VNTR system showed linkage disequilibrium significantly different from zero (EcoRI RFLP/3' APOB VNTR: p < 0.001; AcyI RFLP/TPO VNTR: p < 0.025), thus suggesting that the VNTR arrays are stable. Furthermore, the relationship between the 3' APOB (2p24-p23) and TPO (2pter-p24) VNTR multiallelic systems was also analyzed. The two VNTR polymorphisms were found to be in linkage equilibrium, thus indicating that they can be used together in forensic casework.
在来自意大利南部的100名个体样本中，研究了载脂蛋白B（APOB）基因（EcoRI限制性片段长度多态性/3' APOB可变数目串联重复序列）和甲状腺过氧化物酶（TPO）基因（AcyI限制性片段长度多态性/TPO可变数目串联重复序列）中的连锁不平衡。通过将多等位基因数据重新编码为双等位基因数据，每个限制性片段长度多态性-可变数目串联重复序列系统均显示出连锁不平衡显著不同于零（EcoRI限制性片段长度多态性/3' APOB可变数目串联重复序列：p < 0.001；AcyI限制性片段长度多态性/TPO可变数目串联重复序列：p < 0.025），因此表明可变数目串联重复序列阵列是稳定的。此外，还分析了3' APOB（2p24 - p23）和TPO（2pter - p24）可变数目串联重复序列多等位基因系统之间的关系。发现这两个可变数目串联重复序列多态性处于连锁平衡状态，因此表明它们可在法医案件工作中一起使用。
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