Tsuge I, Suzuki K, Moribe K, Motai H, Kimura T, Umeda K, Kobayashi T, Yokota A, Hondo J, Baba S
Department of Otorhinolaryngology, Toyohashi City Hospital, Japan.
Acta Otolaryngol Suppl. 1996;525:129-34.
Granulocyte colony-stimulating factor (G-CSF) is believed to be useful for shortening the duration of granulocytopenia and for minimizing the decrease in the granulocyte count caused by chemotherapy for non-Hodgkin's lymphoma. In the present study we investigated the effect of G-CSF on bone marrow suppression caused by chemotherapy for non-Hodgkin's lymphoma of the head and neck. The leukocyte and neutrophil nadirs were significantly higher, while the duration of leukopenia, the time to recovery, and the time to the nadir were significantly shorter when G-CSF was administered prophylactically from 48 h after the completion of chemotherapy than when it was administered after the leukocyte and neutrophil counts had reached nadir. G-CSF had no influence on other blood cell components and caused no severe adverse events.
粒细胞集落刺激因子（G-CSF）被认为有助于缩短粒细胞减少的持续时间，并将非霍奇金淋巴瘤化疗引起的粒细胞计数下降降至最低。在本研究中，我们调查了G-CSF对头颈部非霍奇金淋巴瘤化疗引起的骨髓抑制的影响。与在白细胞和中性粒细胞计数达到最低点后给予G-CSF相比，在化疗结束后48小时开始预防性给予G-CSF时，白细胞和中性粒细胞的最低点显著更高，而白细胞减少的持续时间、恢复时间和达到最低点的时间显著更短。G-CSF对其他血细胞成分没有影响，也没有引起严重的不良事件。
