Polednak A P
Connecticut Tumor Registry, Connecticut Department of Public Health, Hartford, USA.
Conn Med. 1996 Sep;60(9):527-30.
Trends in breast-conserving surgery (BCS) rates among 12,745 early-stage invasive breast cancers diagnosed in 1988-94 in Connecticut residents supported the effects of dissemination (around 1990) of results of clinical trials. The lack of decline in BCS from 1993 to 1994 did not support concerns about the effect of negative publicity (in early 1994) regarding fraudulent data from a large clinical trial of BCS vs modified radical mastectomy. The BCS rate reached 75% for node-negative cancers 2 cm or less in diameter diagnosed at age < 60 years in 1994, although it was lower (and declined with age) for larger and/or node-positive cancers. Further study is needed on the decision-making process regarding BCS and its full implications for the quality of life of the large numbers of women diagnosed each year with breast cancer.
1988 - 1994年在康涅狄格州居民中确诊的12745例早期浸润性乳腺癌患者的保乳手术（BCS）率趋势，证实了（约1990年）临床试验结果传播的影响。1993年至1994年BCS率未下降，这并不支持人们对（1994年初）关于一项BCS与改良根治性乳房切除术大型临床试验欺诈数据的负面宣传影响的担忧。1994年，对于年龄＜60岁、直径2厘米及以下的淋巴结阴性癌症患者，BCS率达到75%，不过对于更大和/或淋巴结阳性癌症患者，该比率较低（且随年龄下降）。对于BCS的决策过程及其对每年大量确诊乳腺癌女性生活质量的全面影响，仍需进一步研究。
