Joglekar S J, Nanivadekar A S
Medical & Research Division, Pfizer Ltd, Bombay.
Indian Heart J. 1996 Jul-Aug;48(4):371-4.
A number of coronary heart disease (CHD) risk factors such as dyslipidaemia and diabetes are known to coexist along with hypertension, itself a major CHD risk factor. Indian data on the coexistence of these risk factors is scanty. Epidemiologic studies in India have focused more on the prevalence of CHD in various communities or the correlation of various risk factors with CHD. However, we could not find any large-scale study showing the prevalence of lipid and glycaemic abnormalities in hypertensive patients. This retrospective survey was therefore carried out to estimate the prevalence of metabolic (lipid and glycaemic) abnormalities in hypertensive subjects. The records of persons coming for a health check-up at the Apollo hospitals were screened to obtain 501 consecutive evaluable records of patients who had hypertension or were taking antihypertensive drugs. We found that in 57 percent of these, the levels of total cholesterol were > or = 200 mg/dl and in 37 percent, LDL cholesterol was > or = 130 mg/dl. An elevated ratio of total to HDL cholesterol (> 4.5) was present in 11 percent of patients. Serum triglycerides were > or = 200 mg/dl in 30 percent, and > or = 400 mg/dl in 6 percent. Thirty-six percent of all the hypertensives were either on antidiabetic drugs or had fasting blood sugar values of more than 120 mg/dl. Our findings are thus in agreement with those for the Western population.
已知许多冠心病(CHD)危险因素,如血脂异常和糖尿病,与高血压并存,而高血压本身就是主要的冠心病危险因素。关于这些危险因素并存的印度数据很少。印度的流行病学研究更多地集中在不同社区冠心病的患病率或各种危险因素与冠心病的相关性上。然而,我们找不到任何大规模研究显示高血压患者血脂和血糖异常的患病率。因此,开展了这项回顾性调查,以估计高血压患者代谢(血脂和血糖)异常的患病率。对在阿波罗医院进行健康检查的人员记录进行筛选,以获得501例连续可评估的高血压患者或正在服用降压药患者的记录。我们发现,其中57%的患者总胆固醇水平≥200mg/dl,37%的患者低密度脂蛋白胆固醇≥130mg/dl。11%的患者总胆固醇与高密度脂蛋白胆固醇比值升高(>4.5)。30%的患者血清甘油三酯≥200mg/dl,6%的患者≥400mg/dl。所有高血压患者中,36%的患者正在服用抗糖尿病药物或空腹血糖值超过120mg/dl。因此,我们的研究结果与西方人群的研究结果一致。