Makhdoomi K R, Chalmers J, Campbell I W, Browning G G
Department of Surgery, Victoria Hospital, Kirkcaldy, Fife, UK.
J R Coll Surg Edinb. 1996 Oct;41(5):351-3.
Primary hyperparathyroidism (PHP) is most common in adults in the fifth and sixth decades of life, but is seen infrequently in adolescence and is extremely rare in children under the age of 14 years. We report the case of a young female whom we suspect had PHP from the age of 6 years. This condition remained undiagnosed for the next 11 years in spite of repeated hospital admissions. The hypercalcaemia which was initially labelled as 'idiopathic' was eventually found to be secondary to a parathyroid adenoma, which was treated successfully by surgery. The case illustrates two important advances: (1) in parathyroid hormone measurement with a new sensitive immuno-radiometric assay, and (2) in the development of radionuclide scanning for localization of parathyroid adenoma(s). No case of hypercalcaemia should be labelled as 'idiopathic' or left unexplained without a detailed exploration of the neck to exclude PHP arising from a parathyroid adenoma.
原发性甲状旁腺功能亢进症（PHP）在50至60岁的成年人中最为常见，但在青少年中很少见，在14岁以下儿童中极为罕见。我们报告了一例年轻女性病例，我们怀疑她从6岁起就患有PHP。尽管多次住院，但在接下来的11年里，这种情况一直未被诊断出来。最初被标记为“特发性”的高钙血症最终被发现是由甲状旁腺腺瘤引起的，通过手术成功治疗。该病例说明了两个重要进展：（1）采用新的敏感免疫放射测定法测量甲状旁腺激素，以及（2）放射性核素扫描用于甲状旁腺腺瘤定位的发展。在没有详细探查颈部以排除甲状旁腺腺瘤引起的PHP的情况下，任何高钙血症病例都不应被标记为“特发性”或未得到解释。
