Nasmyth K
I.M.P., Vienna, Austria.
Trends Genet. 1996 Oct;12(10):405-12. doi: 10.1016/0168-9525(96)10041-x.
It might now seem obvious that the mechanisms regulating cell division would be found to be a highly conserved feature of eukaryotic cells. This was less clear 20 years ago when the pioneering genetic studies of the cell cycle were initiated. This article presents one view as to what lies at the heart of the budding yeast cell cycle. It is written on the premise that most of the key players, such as cyclin-dependent kinases, the anaphase-promoting complex, the origin recognition complex, Cdc6p and Mcm proteins, were performing similar functions in the common ancestor of yeast and man. Ideas about the budding yeast cell cycle might, therefore, have universal significance for other eukaryotic cells.
现在看来，调节细胞分裂的机制是真核细胞高度保守的特征，这一点似乎显而易见。20年前，当细胞周期的开创性遗传学研究开始时，情况还不那么明朗。本文就出芽酵母细胞周期的核心内容提出了一种观点。其写作前提是，大多数关键因子，如细胞周期蛋白依赖性激酶、后期促进复合体、起源识别复合体、Cdc6p和Mcm蛋白，在酵母和人类的共同祖先中发挥着类似的功能。因此，关于出芽酵母细胞周期的观点可能对其他真核细胞具有普遍意义。
